mm251: Stem cells – Lab harvests from embryos non-destructively

January 12, 2008

MUDGE’S Musings

Stem cell research is simultaneously a neocon hot button, and one of medical science’s most promising magic bullets.

As a prototypical aging Baby Boomer, yr (justifiably) humble svt has made stem cell research a frequent topic in this nanocorner of the ‘Sphere©:

Stem Cell Research: Support it now!

mm251: Stem cells – Lab harvests from embryos…
mm230: Stem cells…
mm:221: The dread disease … Old age
mm201: Stemming the tide of ignorance
mm200: Stem cells: Unlike oil… alternative source
mm172: Diabetes: Not so Simple, Simon!
mm171: Maintain your brain!

George III, our presidential protector of evangelical Christian values (and please don’t confuse him with the facts), has stifled medical research based on stem cells, on the grounds that the source of the research material was purported to be aborted fetuses.

Recently, researchers have concentrated on finding less controversial sources for stem cells. The latest breakthrough was reported in Friday’s Washington Post.

washingtonpost

Lab Cites Stem Cell Advance

By Rick Weiss

Washington Post Staff Writer | Friday, January 11, 2008; Page A04

Scientists in Massachusetts said yesterday that they had created several colonies of human embryonic stem cells without harming the embryos from which they were derived, the latest in a series of advances that could speed development of stem-cell-based treatments for a variety of diseases.

In June, scientists in Japan and Wisconsin said they had made cells very similar to embryonic stem cells from adult skin cells, without involving embryos. But that technique so far requires the use of gene-altered viruses that contaminate the cells and limit their biomedical potential.

By contrast, the new work shows for the first time that healthy, normal embryonic stem cells can be cultivated directly from embryos without destroying them.

Of course, the Bush administration is not taking this advance at face value.

But that is not likely, said Story Landis, who heads the National Institutes of Health Stem Cell Task Force, which oversees grants for studies on the medically promising cells.

The embryos Lanza used, which were donated for research, appear not to have been damaged, Landis acknowledged. However, she said, “it is impossible to know definitively” that the embryos were not in some subtle way harmed by the experiment. And “no harm” is the basis of the Bush policy, she said.

The science in question was a technical tour de force:

“It is a technically impressive piece of work,” said Douglas A. Melton of the Harvard Stem Cell Institute. “They’ve demonstrated their ability to isolate human embryonic stem cell lines without destruction of the embryos” — something few scientists thought possible just a few years ago.

[Please click the link below for the complete article — but then please come on back!]

Lab Cites Stem Cell Advance – washingtonpost.com

Lest we lose site of what all of the shouting is about, Wikipedia has a useful research timeline.

The possibilities for using stem cells to provide breakthrough solutions to what have been incurable, mysterious and tragic diseases such as Parkinson’s, Alzheimer’s, ALS (Amyotrophic lateral sclerosis, sometimes called Lou Gehrig’s Disease) and diabetes are compelling. And the tragedy has been compounded by the typically ignorant, anti-science stance of the Bush administration.

When will evangelicals wake up and learn that science isn’t the opposite of religion, that the two are not mutually incompatible?

Meanwhile, January 20, 2009 (as this is written, 373 days, 6 hours, 46 minutes, 40 seconds from now) cannot get here soon enough!

It’s it for now. Thanks,

–MUDGE

Note!: the link to Bushtimer.com used above is for clever illustration purposes only and represents no commercial relationship whatsoever. Left-Handed Complement should be so fortunate as to ever collect remuneration of any kind for this endeavor. I can link, so I link. It’s technology. It’s cool. It’s an artifact of Sequitur Service©. Deal with it.

Share this post : del.icio.us it! digg it! reddit! technorati! yahoo!


mm201: Stemming the tide of ignorance despite the neocons

November 22, 2007

MUDGE’S Musings

Last post, we picked up on the report that stem cell researchers have an alternative source for the miracle tools. The writer of that NYTimes story follows up with a sidebar on the lead scientist, James A. Thomson of the University of Wisconsin, who has played a leading, even defining, role in stem cell research for more than a decade.

nytimes3_thumb1

By GINA KOLATA

If the stem cell wars are indeed nearly over, no one will savor the peace more than James A. Thomson.

Dr. Thomson’s laboratory at the University of Wisconsin was one of two that in 1998 plucked stem cells from human embryos for the first time, destroying the embryos in the process and touching off a divisive national debate.

And on Tuesday, his laboratory was one of two that reported a new way to turn ordinary human skin cells into what appear to be embryonic stem cells without ever using a human embryo.

Turns out that Dr. Thomson was, as he and his UW colleagues report it, concerned about the ethical implications of stem cell research from the beginning.

[Please click the link below for the complete article — but then please come on back!]

Man Who Helped Start Stem Cell War May End It – New York Times

Some of the commentary others in the blogosphere have shared since the original story hit the other day have expressed a good deal of knee-jerk cynicism regarding the nature of this latest twist. It’s just so perfect that this latest news fits so well with Bush administration dogma. See, you can do your research without abortion!

People, this isn’t politics, or religion; it’s science. Forced by ethical, political and/or religious imperatives to curtail stem cell research, many wrung their hands, took off to more scientifically adventurous locales, or found a new field to pursue.

Thomson, and, separately, Shinya Yamanaka of Kyoto University, decided that the potential for breakthrough discoveries was too important, and figuratively lit a candle rather than curse the darkness, and began the work that resulted in this weeks breakthrough announcements.

MUDGE chooses to suspend cynicism (after all, it’s a holiday in the U.S. today!), and believe the best. Okay, so this fits with distorted agenda of the neo-con know-nothings who have distorted too much and spread a huge swath of medieval ignorance over too much of our culture.

But, sometimes, even good news for the dolts is good news for humankind, and this discovery, whose potential to accelerate further discoveries into the cause, prevention and cure of many neurological diseases that have caused such misery in the world, is worthy of our Thanksgiving celebration.

It’s it for now. Thanks,

–MUDGE


mm200: Stem cells: Unlike oil, we now have an alternative source

November 21, 2007

MUDGE’S Musings

Stem cell research, emblematic of all that’s promising regarding the ability of scientists to remedy hitherto incurable diseases. Stem cell research, emblematic of the George III administration’s wrong-headedness in nearly every important issue of our times.

Until yesterday, stem cell researchers found their most promising source material in human embryos, whose availability is, one presumes, mainly dependent upon the supply resulting from aborting pregnancies.

Since 1973, such supplies have been legally available to science in the U.S. Since the Bush administration outlawed the practice (or severely curtailed the use of new embryonic material by restricting federal funds required to finance it), researchers into cures for the crippling and fatal diseases that include multiple sclerosis, ALS (amyotrophic lateral sclerosis, Lou Gehrig’s disease), Parkinson’s and Alzheimer’s have been thwarted from fully pursuing this most promising field of research.

Now it appears that scientists have discovered an alternative to embryos as the feedstock for stem cells.

nytimes3

By GINA KOLATA

Published: November 21, 2007

Two teams of scientists reported yesterday that they had turned human skin cells into what appear to be embryonic stem cells without having to make or destroy an embryo — a feat that could quell the ethical debate troubling the field.

All they had to do, the scientists said, was add four genes. The genes reprogrammed the chromosomes of the skin cells, making the cells into blank slates that should be able to turn into any of the 220 cell types of the human body, be it heart, brain, blood or bone. Until now, the only way to get such human universal cells was to pluck them from a human embryo several days after fertilization, destroying the embryo in the process.

Science in the pursuit of prevention or remediating disease is critical, and the fact that it has been hamstrung over this moral quandary, mainly promoted by those same folks who brought you Creationism, is yet another embarrassing lowlight of the past seven years.

So much of what research has been occurring moved offshore (as so many other occupations have). But, science is always attempting to navigate new ways around knowledge gaps, and this promising achievement is an eye-opening demonstration.

[Please click the link below for the complete article — but then please come on back!]

Scientists Bypass Need for Embryo to Get Stem Cells – New York Times

So there’s much work left to do before this new process is proven successful — the fact that a cancer gene is part of the process sounds distressing — but we can’t help but be hopeful that, after years of roadblocks, necessary research into the causes, prevention and cures of some of the most dreadful diseases can resume at full throttle.

In the long run, the new process might prove to be more useful, with wider application than the controversial one. So in a way, maybe the know-nothings did science a favor.

Irony. Today’s sixth sense.

It’s it for now. Thanks,

–MUDGE